Search results for "Environmental ionizing radiation"

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Fibroblasts from bank voles inhabiting Chernobyl have increased resistance against oxidative and DNA stresses

2018

Background Elevated levels of environmental ionizing radiation can be a selective pressure for wildlife by producing reactive oxygen species and DNA damage. However, the underlying molecular mechanisms that are affected are not known. Results We isolated skin fibroblasts from bank voles (Myodes glareolus) inhabiting the Chernobyl nuclear power plant accident site where background radiation levels are about 100 times greater than in uncontaminated areas. After a 10 Gy dose of gamma radiation fibroblasts from Chernobyl animals recovered faster than fibroblasts isolated from bank voles living in uncontaminated control area. The Chernobyl fibroblasts were able to sustain significantly higher do…

Male0301 basic medicinep53Antioxidantmedicine.medical_treatment010501 environmental sciences01 natural sciencesAntioxidantsIonizing radiationsäteilybiologiachemistry.chemical_classificationCell DeathbiologyArvicolinaelcsh:CytologyBank volefibroblastitOxidantshumanitiesCell biologyAntioxidant capacityBank voleResearch ArticleG2 PhaseCell SurvivalDNA damagemetsämyyräOxidative phosphorylationCell LineMicrobiologyChernobyl03 medical and health sciencesmedicineAnimalsEnvironmental ionizing radiationlcsh:QH573-671Geneoksidatiivinen stressi0105 earth and related environmental sciencesantioksidantitReactive oxygen speciesCell Cycle CheckpointsDNACell BiologyFibroblastsbiology.organism_classificationresistenssiOxidative Stress030104 developmental biologyChernobyl Nuclear AccidentchemistryGamma RaysApoptosisbank volesDNA damageTumor Suppressor Protein p53BMC Cell Biology
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